Other facets of mitochondrial antioxidant in ophthalmology

Abstract

The role of oxidative stress in the development and progression of age-related diseases in ophthalmology sufficiently studied and proven. However application mitohondrail antioxidant is not enough studied under these pathologies.

Objective: To investigate the clinical efficacy Vizomitin with age-related cataract and its influence on the parameters of hydrodynamics eyes.

Materials and methods. A clinical study of 2 groups of patients (age 63,8 ± 4,3 years). One group – with age-related cataract in the initial stage, which was appointed Vizomitin® 1–2 drops 3 times a day. Patients of the second group received instillation hypromellose. Results. After 4 months of treatment, the difference in the visual acuity in the study group became true and was 0.1 in podruppe I and 0.05 in the subgroup II (p < 0.05 relative to the same sub-groups at the beginning of treatment). Patients with Vizomitin group after the first month and 4 months after the application was observed a slight tendency to increased intraocular pressure. Also, patients in group I ease the outflow coefficient during the initial survey was 0,28 ± 0,01 and decreased during the second examination after 1 month to 0,25 ± 0,01 difference was not significant. Minute volume of chamber moisture in group I patients at initial assessment was 1,9 ± 0,2 and increased after 1 month to 2,46 ± 0,2 (p < 0.05) and remained the same over the next 3 months.

Conclusion. Appointment Vizomitin in patients with an initial stage of cataract leads to a positive therapeutic effect (increase in visual acuity). Patients who used Vizomitin significantly change the hydrodynamic performance. After a month of application is increased production of intraocular fluid and increases its outflow in 4 months.